![]() This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: Researchers from public institutions can submit a collaboration request including information on the institution and a brief description of the project to All requests will be reviewed by the steering committee of the NutriNet-Santé study. Received: NovemAccepted: FebruPublished: March 24, 2022Ĭopyright: © 2022 Debras et al. PLoS Med 19(3):Īcademic Editor: Wei Zheng, Vanderbilt University School of Medicine, UNITED STATES (2022) Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study. Limitations of this study include potential selection bias, residual confounding, and reverse causality, though sensitivity analyses were performed to address these concerns.Ĭitation: Debras C, Chazelas E, Srour B, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, et al. Higher risks were also observed for breast cancer ( n = 979 cases, HR = 1.22, P = 0.036, for aspartame) and obesity-related cancers ( n = 2,023 cases, HR = 1.13, P = 0.036, for total artificial sweeteners, and HR = 1.15, P = 0.026, for aspartame). In particular, aspartame (HR = 1.15, P = 0.002) and acesulfame-K (HR = 1.13, P = 0.007) were associated with increased cancer risk. Compared to non-consumers, higher consumers of total artificial sweeteners (i.e., above the median exposure in consumers) had higher risk of overall cancer ( n = 3,358 cases, hazard ratio = 1.13, P-trend = 0.002). Associations between sweeteners and cancer incidence were assessed by Cox proportional hazards models, adjusted for age, sex, education, physical activity, smoking, body mass index, height, weight gain during follow-up, diabetes, family history of cancer, number of 24-hour dietary records, and baseline intakes of energy, alcohol, sodium, saturated fatty acids, fibre, sugar, fruit and vegetables, whole-grain foods, and dairy products. Dietary intakes and consumption of sweeteners were obtained by repeated 24-hour dietary records including brand names of industrial products. Questions in violation of this rule will be removed or locked.Overall, 102,865 adults from the French population-based cohort NutriNet-Santé (2009–2021) were included (median follow-up time = 7.8 years). Specific assistance questions are allowed so long as they follow the required assistance post guidelines. General open ended career and getting started posts are only allowed in the pinned monthly getting started/careers thread. Problem you are attempting to solve with high specificity.Research you have completed prior to requesting assistance.If you are asking for assistance on a problem, you are required to provide If you post such content on any other day, it will be removed. Sharing your project, portfolio, or any other content that you want to either show off or request feedback on is limited to Showoff Saturday. We do not allow any commercial promotion or solicitation. Please refer to the Reddit 9:1 rule when considering posting self promoting materials. Read and follow reddiquette no excessive self-promotion. ![]() Check out /r/ProgrammerHumor/ for this type of content. Specific issues that follow rule 6 are allowed.ĭo not post memes, screenshots of bad design, or jokes. For vague product support questions, please use communities relevant to that product for best results. ![]() No vague product support questions (like "why is this plugin not working" or "how do I set up X"). Beginner question? Try the FAQ first! or the WebDev Resources Post then post in the Beginner Questions thread. ![]()
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